Why Are Cell Populations Maintained via Multiple Intermediate Compartments?

Explore the importance of multiple intermediate compartments in maintaining cell populations through this lecture from the Santa Fe Institute. Delve into the challenges of maintaining product cells from progenitor cells, examining how a single intermediate compartment can lead to undesirable outcomes such as clonal dominance and excessive cell divisions. Discover why a sequence of compartments offers a more efficient approach, minimizing clonality and optimizing the number of division rounds. Gain insights into T cell activation, cellular organization, stochastic elimination, and T cell development exhaustion. Examine the stochastic rules of cellular fate and analyze probability distributions related to compartment numbers. Enhance your understanding of complex biological systems and their implications for cell population maintenance.

Introduction
Overview
T cell activation
Cellular organization
Stochastic elimination
Tcell development exhaustion
Stochastic rules of cellular fate
Definition of multiple intermediate compartments
Question
Probability
Properties
Random variables
Probabilities
Generation
Probability distribution
Number of compartments
Conclusion
Discussion