Leveraging Advancements in Genomics to Prevent Gastric Cancer

Explore the cutting-edge research on preventing gastric cancer through genomic advancements in this 15-minute conference talk from the 2022 Gastric Cancer Summit. Presented by Dr. Hanlee Ji from Stanford University, delve into long-term objectives and the progression of integrative cellular genomics. Examine conventional gene expression techniques and study samples, comparing histopathology findings. Discover the power of spatial transcriptomics in cell mapping and localizing gene expression to specific cell types. Compare findings with gastric cancer cases and investigate gene mapping in relation to metaplasia, dysplasia, and cancer. Gain insights into gastric intestinal metaplasia analysis, epithelial cell type assignment, and cell mapping of metaplasia components. Conclude with a comprehensive summary of the research, acknowledging contributors and support for this groundbreaking work in gastric cancer prevention.

Intro
Long term objectives
Overview
Progression
Integrative cellular genomics
Conventional gene expression
Study samples
Histopathology comparison
Spatial transcriptomics - cell mapping
Localizing gene expression to cell type
Comparison with gastric cancer
Gene mapping
Mapping to metaplasia - high risk genes
Mapping to metaplasia - high cell resolution
Mapping to dysplasia and cancer
Gastric intestinal metaplasia analysis
Epithelial cell type assignment
Cell mapping of metaplasia components
Summary
Acknowledgements
Support