Abnormal Mechanics in Brain Tumors: Implications for Immunotherapy

Explore the implications of abnormal mechanics in brain tumors for immunotherapy in this 56-minute seminar by Dr. Meenal Datta. Delve into the challenges faced by glioblastoma patients and the potential role of the tumor microenvironment in treatment resistance. Learn about "solid stress," a mechanical force that compresses blood vessels, induces hypoxia and immunosuppression, and hinders immunotherapy efficacy. Discover findings from patient and mouse model studies demonstrating how solid stress can be measured and applied in vivo, damages surrounding healthy brain tissue, and can be targeted to restore neurological function and overcome immunotherapy resistance. Gain insights into mechanical models, methods for measuring solid stress, and strategies to target it, including the use of Losartan to enhance therapeutic outcomes and improve immune checkpoint blockade efficacy. Understand the complex interplay between tumor mechanics, the immune microenvironment, and treatment response in glioblastoma.

Monthly Seminar on Physical Genomics April 28, 2023
Outline
My research experiences
Abnormal tumor microenvironment fuels treatment resis
Tumors harbor mechanopathologies including 'solid str
Solid stress compresses blood vessels in the surroundi
Solid stress is correlated with neurological dysfunction in
Mechanical model to apply solid stress in vivo for causal stud
Chronic compression reduces neurological function
Methods to measure and map solid stress ex vivo
Solid stress is a mechanical biomarker of treatment resp
Strategies to target solid stress
Losartan enhances therapeutic outcomes in extracranial
Losartan overcomes solid stress effects in GBM mouse
Losartan promotes cytotoxic T cell function in GBM
Losartan repolarizes the myeloid compartment in GE Pro-tumor myeloid cells
Losartan improves immune checkpoint blockade effi
Bihemispheric model predicts response to combination
Immune checkpoint blockade exacerbates GBM ede
Tumor Immune Microenvironment and Mechanics Lab