Integrative Models of the Cardiac Ventricular Myocyte - 2005

Explore an in-depth lecture on integrative modeling of cardiac ventricular myocytes presented by Raimond Winslow from Johns Hopkins University. Delve into the history and significance of biophysically-based cell models in cardiac electrophysiology, with a focus on the ventricular myocyte due to its relevance to arrhythmia and heart disease. Examine the crucial process of Ca2+-Induced Ca2+-Release (CICR) and its role in muscle contraction and action potential regulation. Discover the limitations of current CICR models and gain insights into developing more accurate reconstructive and predictive models for investigating myocyte function in health and disease. Learn about action potentials, membrane potentials, and time rate of change in cardiac cells. Explore the applications of these models in whole heart simulations, including imaging techniques and finite difference models. Understand the importance of this research in addressing critical issues such as polymorphic ventricular tachycardia.

Introduction
Presentation
The Cardiac Ventricular Myocyte
Action Potential
Membrane Potential
Time Rate of Change
Model Overview
Mechanisms
Experimental Results
Modeling in a Whole Heart
Imaging the Heart
Finite Difference Model
Why is this important
Polymorphic VT