How Life Changes Itself - The Read-Write Genome

Explore the fascinating world of genomic inscriptions and their role in biological functions across various time scales in this 39-minute lecture by James Shapiro, PhD, from the University of Chicago. Delve into the processes organisms use to merge and modify their genomes, generating new taxonomic groups. Learn about the biological activities cells employ to create novel configurations of their read-write genomes. Discover different classes of genome inscriptions, including transient nucleoprotein complexes and horizontal transfer mechanisms. Examine the Natural Genetic Engineering Toolbox and its impact on evolutionary processes. Investigate how mobile elements alter genome function and the activation of natural genetic engineering by multiple stimuli. Gain insights into the targeting of natural genetic engineering through protein-protein interactions in this comprehensive presentation from the American Society for Microbiology's virtual lecture series.

Intro
Genome reading & maintenance require prior inscriptions (formatting)
Different classes of genome inscription • Transient nucleoprotein complexes - Largely within the cell cycle - Replication and transcription initiation complexes, repair
Within the cell cycle: Genome writing by nucleoprotein complexes
horizontal transfer and natural genetic engineering-bacterial antibiotic resistance
horizontal transfer - nematode plant parasitism
Natural Genetic Engineering Toolbox
Evolutionary time: Genome writing by natural genetic engineering - dispersed mobile elements
Evolutionary time: Genome writing - Wexonization of mobile element inserts for new protein domains
Evolutionary time: Genome writing by natural genetic engineering -mobile elements alter genome function in many ways
Activation of natural genetic engineering by multiple stimuli
Targeting of natural genetic engineering (retrotransposition) by protein-protein interactions