Innovation by Evolution - Bringing New Chemistry to Life

Explore a groundbreaking lecture on protein engineering and enzyme evolution delivered by Nobel laureate Frances Arnold. Delve into the innovative use of directed evolution to create new protein catalysts and expand the realm of genetically encoded enzyme functions. Learn how Arnold harnesses the power of evolutionary processes to optimize existing enzymes and invent new ones, overcoming limitations in our understanding of sequence-function relationships. Discover the vast potential of this approach in creating novel chemical reactions, including the formation of carbon-silicon bonds and its implications for fields like astrobiology. Gain insights into the adaptability of evolutionary methods across various chemical challenges, from bicyclobutane synthesis to beta-lactam antibiotics. Understand the broader impact of this research on the future of chemistry and its potential applications in the Internet of Things.

Intro
The universe of possibilities
The challenge of the Evolver
John Maynard Smith
Enzymes
Party
Nobel Prize
What we learned
Evolution is a great innovator
Enzymes are graduate students
An example
Bicyclobutane
Cyclobutane
Carbon silicon bonds
Wildtype protein
cytochrome C
crystal structure
siliconbased life
astrobiology magazine
whats the message
biology doesnt touch well
evolution is one size fits all
betalactams
a future of chemistry
Internet of things