Elevated Anion Gap Metabolic Acidosis - ABG Interpretation

Explore a comprehensive 43-minute video lecture on elevated anion gap metabolic acidosis, focusing on lactic acid, ketoacids, and toxic alcohols. Delve into the differential diagnosis, including renal failure, oxoproline, toluene, and paraldehyde. Learn about the formation and sources of lactate, medications associated with lactic acidosis, and the unique aspects of D-lactic acidosis. Examine ketoacidosis pathways, including those specific to alcoholics. Investigate the role of ethylene glycol, propylene glycol, and methanol in metabolic acidosis, and understand the concept of serum osmolal gap. Gain insights into the y-glutamyl cycle and its relevance to toluene-induced acidosis.

Intro
Learning Objectives
Etiologies of an Elevated Gap Acidosis
Formation of Lactate
Sources and Elimination of Lactate
Medications and Toxins Associated with Lactic Acidosis
Metformin and Lactic Acidosis
D-Lactic Acidosis
Lactic Acidosis (An alternate classification system)
Ketoacidosis
Formation of ketoacids
Additional Pathway for ketoacids in Alcoholics
Acidosis in Renal Failure
Ethylene Glycol
Propylene Glycol
Serum Osmolal Gap
Methanol and the Osmolal Gap
Toluene
y Glutamyl Cycle