Elevated Anion Gap Metabolic Acidoses - Understanding ABGs

Explore the differential diagnosis and diagnostic work-up of elevated anion gap metabolic acidosis in this abridged 24-minute lecture. Learn about various etiologies, including lactic acidosis, ketoacidosis, and renal failure-associated acidosis. Understand the formation and sources of lactate, medications linked to lactic acidosis, and the unique D-lactic acidosis. Delve into ketoacid formation, acidosis in renal failure, and the effects of toxins like methanol, ethylene glycol, propylene glycol, and toluene. Gain insights into the serum osmolal gap and its significance in diagnosing certain metabolic acidoses.

Intro
Learning Objectives
Etiologies of an Elevated Gap Acidosis
Formation of Lactate
Sources and Elimination of Lactate
Medications and Toxins Associated with Lactic Acidosis
D-Lactic Acidosis
Ketoacidosis
Formation of ketoacids
Acidosis in Renal Failure
Methanol
Ethylene Glycol
Propylene Glycol
Serum Osmolal Gap
Toluene