Clinical and Genetic Determinants of Contralateral Breast Cancer - Webinar - Ambry Genetics

Explore the clinical and genetic determinants of contralateral breast cancer in this informative webinar presented by Dr. Katharine Yao, Chief of Surgical Oncology at NorthShore University HealthSystem. Delve into the risk factors for contralateral breast cancer in newly diagnosed patients, with a particular emphasis on the impact of family history and genetic mutations. Learn about the application of risk models and prediction tools in clinical settings. Gain insights into treatment preferences, bilateral mastectomy rates, and the effects of anti-estrogen treatment and radiation therapy on contralateral breast cancer risk. Examine the prevalence of genetic mutations across different racial and ethnic groups, and understand the implications of BRCA and non-BRCA genes on contralateral breast cancer risk. Discover the Manchester Guidelines, prediction models, and their clinical applications. Analyze the relationship between contralateral prophylactic mastectomy and survival rates, considering potential selection biases. Conclude by exploring patient motivations for choosing contralateral prophylactic mastectomy.

Intro
Disclosures
OBJECTIVES
Why is it Important to Know About CBC?
Treatment Preference
Increase in Bilateral Mastectomy Rates
Bilateral Mastectomy Rates are Age Dependent
Overall Surgery Trends for Stage 1-1 Breast Cancer Patients
Risk Factors for CBC
CBC Risk-Clinical Trials
Decreasing CBC with Anti-Estrogen Treatment (ER+ Tumors)
RISK OF CBC and RADIATION THERAPY FOR BREAST CANCER
CBC Risk and Family History Ten Year Cumulative Risks
CBC RISK in BRCA MUTATION CARRIERS-META-ANALYSIS of 20 STUDIES
CBC risk for Non-BRCA Genes
Prevalence of Genetic Mutations 2012-2015
Prevalence of Genetic Mutations by Race/Ethnicity
Conclusions
Manchester Guidelines
CBC Prediction Models
Clinical Application-CBC Prediction
CBC and Survival
Association of CPM with Reduction in Mortality Selection Bias Stage
BRCA carriers and Survival with Bilateral Mastectomy
Why Patients Choose CPM
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