Cell Communication Mediated by Fluid Flows in Development and Disease - Daniel T. Grimes

Explore cell communication mediated by fluid flows in development and disease in this 45-minute conference talk from the Kavli Institute for Theoretical Physics. Delve into the mechanisms of embryonic symmetry breaking, focusing on how fluid hydrodynamics contribute to early developmental decisions. Examine the role of cilia, asymmetric fluid flow, and genetic factors in establishing body plan asymmetries. Learn about the F molecule, PKD1, and their involvement in fluid flow sensing. Discover current models and ongoing research to identify regulators of these processes. Investigate the concept of "hard asymmetry" and the function of motile cilia in axial straightening. Engage with the presented material through a Q&A session, gaining insights into the latest advancements in developmental biology and theoretical physics as they relate to morphogenesis.

Introduction
Asymmetries
Internal asymmetries
Cilia
Asymmetric fluid flow
The F molecule
PKD1 and fluid flow
Model
Genetic work
Questions
Current model
Finding regulators
Hard asymmetry
Motile cilia
Axial straightening
QA
Vijay
Cycling
Question