Modelling Mammalian Early Embryonic Development and Patterning In Vitro With Stem Cells - Berna Sozen

Explore the intricacies of early mammalian embryonic development and patterning in this 32-minute conference talk by Berna Sozen at the Kavli Institute for Theoretical Physics. Delve into the fascinating process of how embryos make their first decisions, separating top from bottom and left from right. Examine the series of symmetry-breaking events that pattern initially homogeneous tissues and sculpt symmetric cell collections into functional organs. Discover the wide range of mechanisms driving symmetry breaking, including nonlinear gene network dynamics, tissue mechanics, and embryonic fluid hydrodynamics. Learn about recent contributions from physicists in developing theories based on symmetry breaking concepts, suggesting a path toward unified principles of development. Gain insights into the latest advancements in the field, aided by modern computational power and new methods in imaging and single-cell techniques. Follow the presentation as it covers key topics such as early embryonic development, model systems, development events, embryogenesis, stem cell polarity, cell movements, and model signaling. Understand the comparison between localized signals, global molecular signatures, and natural embryos. Participate in this thought-provoking discussion that brings together developmental biologists and theoretical physicists to assess the landscape of symmetry breaking processes in development and clarify the path towards a unified theory of morphogenesis.

Introduction
Welcome
Early embryonic development
Model systems
Development events
Design
Embryogenesis
Stem cell polarity
Cell movements
Questions
Key questions
Model signaling
Localized signals
Global molecular signature
Comparison with natural embryos
Summary
Thanks