Mechanism of a Protein Antibiotic in Bacteriophage Lysis - Broad-MIT Seminar 2023

Explore a seminar from the Broad-MIT Seminar Series in Chemical Biology featuring Professor Bil Clemons from Caltech. Delve into the fascinating world of protein antibiotics and their mechanisms, focusing on the single gene lysis (SGL) protein found in bacteriophages. Learn about Protein E from ΦX174, its role in bacterial cell wall lysis, and its interaction with host chaperone SlyD and the essential enzyme MraY. Discover how cutting-edge electron cryo-microscopy techniques have revealed the structure of a three-protein complex, providing new insights into the lysis mechanism and potential implications for developing novel therapeutics. Gain a deeper understanding of the intricate processes involved in bacteriophage life cycles and the importance of peptidoglycan biosynthesis in bacterial cell walls.

Broad-MIT Seminar Series in Chemical Biology: Bil Clemons (2023)