How to Use Antibiotics Without Driving the Evolution of Antibiotic Resistance

Explore the critical issue of antibiotic resistance and innovative strategies to combat it in this hour-long seminar. Delve into the standard solutions and mantras surrounding antibiotic use, and examine the concept of de novo resistance. Learn about groundbreaking research on treatment regimens, including the work of Nina Whale and Kevin Wood at the University of Michigan Hospital. Investigate the challenges posed by VRE (Vancomycin-Resistant Enterococci) and discover potential anti-evolution drugs. Analyze methods for preventing resistance, such as competitive release and the use of probiotics. Gain insights into the complexities of artificially selecting virulent strains and the potential of quorum sensing molecules in the fight against antibiotic resistance. Engage with cutting-edge ideas on evolution-proof approaches and competition-based strategies to address this pressing global health concern.

Introduction
Antibiotic resistance
The standard solution
The mantra
Hit hard and use enough
Denovo resistance
Treatment regimen
Results
Manipulation
Nina Whale
Kevin Wood
University of Michigan Hospital
What is VRE
VRE in mice
Antievolution drugs
Preventing resistance
Competitive release
How easy is it
Difference in virulence
Can we artificially select virulent strains
Probiotics
Mimic competition
Evolution proof
Competition
Research
quorum sensing molecules