Esomeprazole - Drug Testing, Usage, and Clinical Trials

Explore the intricacies of drug testing and usage through the lens of esomeprazole in this 51-minute Yale University lecture from the Freshman Organic Chemistry course. Delve into the chemical mode of action of omeprazole and its stereochemistry, examining the importance of clinical trials in evaluating proposed benefits of chiral switches. Gain insights from otolaryngologist Dr. Dianne Duffey on pharmaceutical testing, marketing, FDA approval processes, clinical trial systems, off-label uses, and the responsibilities in evaluating pharmaceuticals. Investigate the economic aspects of clinical trials, learn about the different phases of testing, and compare results for esomeprazole and omeprazole. Conclude with a discussion on pharmaceutical marketing strategies and participate in a Q&A session. This comprehensive lecture, recorded in Fall 2008, offers a blend of chemistry, medicine, and industry perspectives on drug development and usage.

- Chapter 1. Introduction: The Chemical Properties and Reactivity of Prilosec.
- Chapter 2. The Economics of Clinical Trials.
- Chapter 3. Duffey: How Do I Know that the Drug is Effective? .
- Chapter 4. The Phases of Clinical Trials, Results for Esomeprazole and Omeprazole, and Off-Label Use.
- Chapter 5. Pharmaceutical Marketing Mentality and Q&A.