Warfarin - Mechanism of Action, Indications, Adverse Reactions, Contraindications

Explore the pharmacology of Warfarin in this comprehensive lecture, covering its mechanism of action, indications, adverse drug reactions, and contraindications. Delve into the role of Vitamin K in the coagulation cascade, understand how Warfarin functions as an anticoagulant, and learn about its effects on various proteins involved in blood clotting. Examine important drug interactions, prophylactic uses, and applications in conditions such as atrial fibrillation. Gain insights into monitoring Warfarin therapy through PT/INR tests, and become aware of potential adverse reactions, including bleeding risks, liver failure concerns, and pregnancy-related issues. Enhance your knowledge of this crucial anticoagulant medication to better understand its clinical applications and potential risks.

Intro
Mechanism of Action
Vitamin K
Vitamin K Hydroquinone
Function
Anticoagulants
Warfarin
coagulation cascade
tissue factor
protein
protein C
Drug Interactions
Indications
Prophylaxis
Afib
PTINR
Adverse Drug Reactions
Liver Failure
Pregnancy
Bleeding Risks