Veno-Occlusive Disease by Steven Margossian for OPENPediatrics

Explore a comprehensive 24-minute video lecture on veno-occlusive disease (VOD) after hematopoietic stem cell transplantation. Learn about the definition, pathophysiology, diagnosis, prevention, and management of VOD from Dr. Steven Margossian. Gain insights into clinical presentation, risk factors, diagnostic criteria, and ultrasound findings. Discover preventive measures and management strategies, including fluid and electrolyte management, renal and pulmonary support, and interventional measures such as defibrotide and transjugular intrahepatic portosystemic shunt (TIPS). Understand the classification of VOD and its implications for patient care. This educational content is part of OPENPediatrics, an interactive digital learning platform sponsored by Boston Children's Hospital, offering peer-reviewed, open-access resources for healthcare clinicians worldwide caring for critically ill children.

Intro
Learning Objectives
Clinical Vignette
Clinical Presentation
Risk Factors
Diagnosis: Clinical Criteria
Diagnosis: Hepatic Ultrasound with Doppler
Ultrasound Criteria Supportive of VOD
Preventive Measures
Management of VOD
Classification of VOD
Fluid and Electrolyte Management
Renal Support
Pulmonary Support
Interventional Measures
Defibrotide Risks
Transjugular Intrahepatic Portosystemic Shunt (TIPS)