Update on Celiac Disease

Explore the intricacies of celiac disease in this comprehensive lecture by Dr. Nielsen Fernandez-Becker from Stanford University. Delve into the history, prevalence, and pathophysiology of this genetically linked autoimmune disorder triggered by gluten consumption. Learn about the various clinical manifestations, diagnostic methods including genetic testing, blood tests, and endoscopic findings, and understand the differences between celiac disease, non-celiac gluten sensitivity, and wheat allergy. Gain insights into the challenges of monitoring treatment adherence and managing non-responsive cases. This informative talk covers everything from the basic physiology of the small intestine to the complexities of celiac disease management, providing valuable knowledge for healthcare professionals and individuals interested in this increasingly recognized condition.

Intro
Learning objectives
Celiac Disease: History highlights Earliest description attributed to Areatus of Cappadocia
Celiac Disease prevalence
Small intestinal physiology
Background: Pathogenesis
Genetic testing and celiac disease
Background: Genetic predisposition
Celiac Disease Pathophysiology
Consequences of inflammation: Mucosal Injury
Clinical Consequences of Celiac Disease
Background: Disease manifestations are variable
Non-Celiac Gluten Sensitivity, Wheat Allergy and Celiac
Diagnosis of Non-Celiac Gluten Sensitivities
Non-Celiac Gluten Sensitivity: Potential mechanisms
Mechanisms of wheat mediated effects
Is an elimination diet the best method for distinguishing between celiac disease, wheat allergy and non celiac gluten sensitivity?
Making the diagnosis of Celiac disease: Blood Tests
Endoscopic findings
Histologic Findings
General Work up and Management
Monitoring adherence poses clinical challenge
Non-response or loss of response to Gluten Free diet