The Reluctant Scientist: A Nobel Laureate's Journey Through Medicine and Research

Explore the inspiring journey of Nobel Prize-winning scientist Dr. Robert Lefkowitz in this keynote address titled "The Reluctant Scientist" delivered at the 2013 North Carolina Student Academy of Science conference. Delve into Lefkowitz's life story, from his childhood through medical school and his groundbreaking research on G-protein coupled protein receptors. Gain insights into the lessons learned throughout his career that led to major advancements in prescription drug development for various conditions. Discover the importance of role models, the impact of historical events like the Vietnam War, and the path that led to his Nobel Prize in Chemistry. Learn about the scientific process behind receptor characterization, molecular cloning, and the significance of G-protein coupled receptors in drug targeting. Understand the broader implications of Lefkowitz's work in biology and medicine, including concepts like desensitization and G protein signaling. This 58-minute talk offers a unique perspective on the intersection of medicine and scientific research, providing valuable lessons for aspiring scientists and researchers.

Intro
Importance of Role Models
College
Medical School
Vietnam War
Public Health Service
After NIH
Retirement
Nobel Prize
Chemistry Prize
Receptors in Physiology
Second messengers
Raymond Dahlquist
Lasker Prize
Perspectives of Biology and Medicine
Characterization of Receptors
Receptor Isolation
Solubilize the Receptor
Affinity Chromatography
G Protein
Molecular Cloning
Seven Transmembrane Receptor
Readopsin
Gproteincoupled receptors
Drugs targeting receptors
Desensitization
G protein signaling
Xray crystallography