The Evolution of Gene Expression - From Microevolution to Major Transitions

Explore the complex world of gene regulation and expression in this 44-minute Radcliffe Institute Fellows' Presentation by Thomas Lenormand, CNRS research director and 2017-2018 Hrdy Fellow at Harvard University. Delve into microevolution, macroevolution, and evolutionary theory while examining major transitions in groups, energy, and genetic systems. Investigate the history of prokaryotes and eukaryotes, focusing on reproduction and transcription initiation. Analyze concepts such as trans and cis-regulation, dominance, genetic load, diploidy, and the selfish gene through various metaphors. Examine diploid expression, fitness relationships, and the evolution of regulatory regions. Gain insights into the coevolution of regulators, cis-cis interactions, and the role of regulation in modern synthesis, providing a comprehensive overview of this fascinating field of biology.

Intro
Puzzle in modern biology
Microevolution
Macroevolution
Evolutionary theory
Biodiversity
Questions
Major transitions: groups
Major transitions: Energy
Major transitions: Genetic systems
History
Prokaryotes/Eukaryotes
Eukaryotes reproduction
Eukaryotes transcription initiation
Trans and cis-regulation
Dominance
Genetic load
Diploidy
The selfish gene
Metaphor #1
Metaphor #2
Metaphor #3
Summary part 1
Diploid expression
Expression to fitness
Fixation stronger cis-regulator
Cis-regulator runaway
"Strength" ?
Level of Expression
Coevolution of regulators
Cis-cis coevolution
Summary part II
A theory
Regulatory region evolution
Regulation & Modern synthesis