What's in Your Sweat: Health and Disease Insights - Stanford Radiology PHIND Seminar 2020

Explore the potential of sweat analysis for health monitoring and disease detection in this Stanford Radiology PHIND seminar. Delve into the composition of sweat, its historical context, and the challenges of sweat-based diagnostics. Learn about continuous sweat monitoring techniques and their current applications. Examine a case study on Chronic Kidney Disease, investigating the possibility of detecting metabolic changes in sweat for patients undergoing dialysis. Discover the methodologies used in sweat sample preparation and analysis, including the interpretation of metabolites such as uric acid and fatty acids. Gain insights into the variability of sweat composition and its implications for precision health medicine. Conclude with a discussion on the challenges and future prospects of sweat-based diagnostics in healthcare.

Intro
Vision
What is sweat
Comparison of sweat glands
History of sweat
Three key barriers
Comparing plasma and sweat
Continuous monitoring of sweat
Current use case
Roadmap
Case Study
Chronic Kidney Disease
Dialysis
Why
Human samples
Can we noninvasively detect metabolic changes in sweat
Methodology
Sample Preparation
Results
uric acid
lasso
cross validation
interpreting metabolites
literature
fatty acids
postdialysis
resting sweat variability
summary
challenges
precision health medicine
questions
sweat variability
sample collection