Serum Modulation of Mitochondrial Function as a Sensor of Insulin Resistance

Explore a 48-minute seminar from Stanford University's PHIND series on using serum modulation of mitochondrial function as a scalable sensor for insulin resistance. Delve into the Type 2 Diabetes epidemic, its costs, and the importance of early intervention. Learn about diagnostic testing for insulin sensitivity, including the modified insulin suppression test. Discover how mitochondrial function serves as a sensor for metabolic fuel and environmental factors, and understand the impact of insulin on mitochondrial respiration. Examine the correlation between mitochondrial respiration and insulin sensitivity, as well as personalized responses to diabetes therapeutics. Investigate the role of Fc receptors in insulin resistance and the alterations in IgG Fc region glycosylation. Gain insights from Dr. Andrew Lipchik, a postdoctoral fellow at Stanford University, as he presents his research findings and conclusions on this innovative approach to detecting insulin resistance.

Intro
Type 2 Diabetes Epidemic and Insulin Resisti
Cost of Diabetes
Insulin Resistance Association with Causes of
Early Intervention Influence on Incidence
Progression of Insulin Resistance to Type 2 Dia
Diagnostic Testing for Insulin Sensitivits
Modified Insulin Suppression Test
Mitochondrial Function as a Sensor Environmental Factors
Mitochondria as a Sensor for Metabolic Fue
Impact of Insulin on Mitochondrial Respiga
Cell Type Sensitivity to Insulin
Mitochondrial Insulin Stimulation Test
Serum Modulates Insulin Sensitivity
Mitochondrial Respiration Correlates with
Therapeutics for Type 2 Diabetes
Personalized Responses to Pioglitazori
The Fc Receptors are Necessary for Insulin Resi
IgG Fc Region Glycosylation is Altered
Model of Altered IgG Glycosylation
Conclusions
Acknowledgements Annes lab Justin Annes