Receptor - Agonist and Its Types

Dive into a comprehensive 1-hour 19-minute lecture on receptors, agonists, and their types. Explore the differences between agonists and antagonists, understand various agonist types including full, partial, orthosteric, and allosteric. Learn about affinity, efficacy, and intrinsic activity of ligands. Discover the rationale behind using partial agonists as drugs and examine examples of full and partial agonists in opioid receptors. Investigate positive allosteric modulators, inverse agonists, and the mechanisms of benzodiazepines and barbiturates. Conclude with an overview of direct and indirect agonists, providing a thorough understanding of receptor pharmacology.

00:00:00 - Brief overview of previous lecture
00:01:50 - What is an agonist?
00:03:15 - What is the difference between agonist and antagonist?
00:04:56 - Different types of agonists
00:05:22 - Full agonist
00:06:20 - What is affinity?
00:08:24 - Efficacy of ligand intrinsic activity
00:10:30 - Partial Agonist
00:15:13 - Full agonist vs Partial agonist
00:16:20 - Partial agonists as antagonists
00:20:00 - Rationale of use of partial agonists as drugs
00:24:00 - Examples of full agonists, partial agonists, and opioid receptors
00:28:50 - Orthosteric agonist vs Allosteric agonist
00:35:54 - Positive Allosteric Modulator
00:40:37 - Inverse agonist with examples
00:49:57 - allosteric agonist example
00:51:53 - Positive Allosteric Modulator example
00:52:40 - How Benzodiazepines work
00:59:01 - Benzodiazepines vs Barbiturates
01:03:38 - Direct agonist and Indirect agonists
01:12:32 - Review of the lecture