Quantitative SPECT and Applications in Disease Characterization and Therapy Monitoring

Explore the principles and applications of Quantitative SPECT imaging in this comprehensive 29-minute lecture by Dr. Du from Johns Hopkins Medicine. Delve into topics such as two-camera SPECT/CT systems, imaging agents, and gamma camera technology. Examine analytical methods, effects of attenuation, scatter, and collimator-detector response on image quality. Learn about partial volume effects, statistical noise, and model-based compensation techniques for quantitative reconstruction. Discover practical applications in renal mass imaging, radiopharmaceutical therapy, and dosimetry. Investigate quantitative SPECT activity estimation, bone SPECT, and alpha emitter imaging. Gain insights into advanced techniques like model-based crosstalk compensation and simultaneous dual radionuclide reconstruction, enhancing your understanding of SPECT's role in disease characterization and therapy monitoring.

Intro
Two-Camera SPECT/CT Systems
SPECT Imaging Agents
Gamma Camera
Sample Projection Data
Analytical Method
Effects of Attenuation
Quantitative Effects of Scatter
Effects of CDR on Spatial Frequencies
Effect of CDR on SPECT Images
Partial Volume Effects
Statistical (Quantum) Noise
Effect of Degrading Factors
Quantitative Reconstruction with Model-based Compensation
Renal Mass Imaging
Radiopharmaceutical Therapy
Basic Principles of Dosimetry
Quantitative SPECT Activity Estimation
Quantitative Bone SPECT
Alpha Emitter Example: Ac225
Model Based Crosstalk Compensation and Simultaneous Dual Radionuclide Reconstruction
Conclusions