Vaccine Research Center: Engineering Nanoparticle Platforms for Universal Influenza Vaccines - Presentation 8B

Explore the latest advancements in universal influenza vaccine development through this informative lecture from the NIH Clinical and Translational Research Summer Course. Delve into the challenges posed by influenza diversity and constant mutations, and discover how ferritin nanoparticles are being engineered as a self-assembling vaccine platform. Learn about the protective capabilities of H1N1 HA stem nanoparticles against lethal H5N1 challenges and the stabilization of Group 2 HA stem for heterosubtypic influenza protection. Examine the development of a computationally designed two-component nanoparticle platform and the effectiveness of mosaic nanoparticle vaccines against divergent H1N1 and H3N2 strains, as well as heterosubtypic H5N1 and H7N9 strains. Gain insights into potential career opportunities at the NIH and the unique resources available for clinical and translational research.

Intro
Influenza Diversity and Constant Mutations Highlight the Need For a Universal Influenza Vaccine
Engineering Ferritin Nanoparticles as a Self- Assembling Vaccine Platform
H1N1 HA Stem Nanoparticle Protects Against a Lethal H5N1 Challenge
Stabilization of Group 2 HA Stem Protected Mice From Lethal Heterosubtypic Influenza Challenges
A Computationally Designed Two-Component Nanoparticle Platform
Mosaic Nanoparticle Vaccines Provide Substantial Protection Against Divergent H1N1 and H3N2 Strains
Mosaic Nanoparticle Vaccines Provide Protection Against Heterosubtypic H5N1 and H7N9 Strains