Pharmacology - Cancer Drugs - Antimetabolites

Explore the pharmacology of cancer drugs, specifically antimetabolites, in this comprehensive 13-minute video lecture. Gain a basic understanding of DNA synthesis and the de novo pathways for purine and pyrimidine nucleotide synthesis. Delve into the mechanisms of action and side effects of various antimetabolites used in cancer treatment, including Hydroxyurea, Cladribine, Fludarabine, Gemcitabine, Cytarabine, Fluorouracil, Capecitabine, and Methotrexate. Learn about the uncontrolled growth of abnormal cells in cancer and how these drugs target fast-dividing cells at different phases of the cell cycle. The lecture is structured to cover purine antimetabolites, pyrimidine antimetabolites, and their associated side effects, providing a thorough overview of this important class of cancer drugs.

Intro
De novo synthesis of purines
De novo synthesis of pyrimidines
Purine antimetabolites
Pyrimidine antimetabolites
Side effects