Evolutionary Forces in Humans and Pathogens - Natural Selection and Genomic Studies

Explore a comprehensive 57-minute lecture by Pardis Sabeti from Harvard University on evolutionary forces in humans and pathogens. Delve into the genome revolution's impact on studying human biology, evolution, and disease, as well as its applications in microbial pathogen research. Discover how the Sabeti lab develops and applies methods to investigate natural selection in the human genome and study the genomic evolution of pathogens like Lassa virus, Ebola, Plasmodium Falciparum, and Vibrio Cholerae. Learn about genomic signals of natural selection, genome-wide scans, and the path to adaptive evolution. Examine case studies on pigmentation genes, hair traits, and the EDARV370A mouse model. Gain insights into emerging diseases, public health implications, and the development of diagnostic tools for pathogens like Lassa virus. Understand the importance of combining multiple tests to pinpoint genetic variants and the role of ancient microbes in human evolution.

SCIENCE LECTURE
The Study of Natural Selection
Natural Selection Shaped Human Genome
Overview
Genomics Signals of Natural Selection
The Era of Genome-Wide Scans
Path to Adaptive Evolution
Developed a Composite of Multiple Signals
Combining Multiple Tests to Pinpoint Variants
Many Pigmentation Genes
Chr2: Asia, Hair traits
Human Traits
Mouse model EDARV370A model
Hair and Sweat Evolution
From Genomic Scan to Adaptive Hypothesis
Setting up diagnostic capacity
Sequencing Lassa virus
Lassa Patient
Emerging Disease or Emerging Diagnosis?
Public Health Implications
A Suite of Tools
An Array of Ancient Microbes
Sabeti Lab 2013
The Broad Malaria Community