Novel Therapies for Multiple Myeloma - Closer to a Cure Community Lecture Series

Explore current and emerging treatments for multiple myeloma in this informative community lecture featuring UCLA hematologist and oncologist Dr. Sarah M. Larson. Moderated by Leila Evangelista from the Leukemia & Lymphoma Society, the talk covers a wide range of topics including the immune system, plasma cells, M protein, disease spectrum, and CRAB criteria. Delve into various treatment approaches, response rates, and the concept of minimal residual disease. Learn about cutting-edge therapies such as Venetoclax, immunotherapy targeting BCMA and BLEN, and CAR T-cell treatments, including their side effects and ongoing clinical trials. Gain insights into the latest research, including the Storm, Karma 3, and Karma 4 trials, and discover efforts to design more effective CAR T-cells. The lecture concludes with information on clinical trials and the Climb to Cure initiative, followed by a Q&A session.

Introduction
Objectives
The Immune System
The Plasma Cell
The M Protein
The Spectrum of Disease
The Crab Criteria
Treatment
Response
remission
response rates
complete response
Minimal residual disease
Storm Trial
Venetoclax
Immunotherapy
Targets
BCMA
BLEN Rep
CAR T Cells
CAR T Cells Side Effects
Lymphodepletion
Iacel
Karma 3 Trial
Karma 4 Trial
Clinical Trial Summary
Can We Design a Better CarT Cell
Clinical Trials
Climb to Cure
Thank you
Questions