Non-Transplant Options in Pediatric Acute Liver Failure

Explore non-transplant options for pediatric acute liver failure in this 24-minute World Shared Practice Forum podcast. Learn about management strategies for acutely ill children, associated toxicities, and emerging trends in treatment pathways. Gain insights from Dr. Akash Deep, Director of the Pediatric Intensive Care Unit at King's College Hospital, as he discusses his recent publication and the evolving paradigm shift in the field. Apply strategies for managing acute liver failure, understand common toxicities, and discover the latest developments in pediatric critical care. Delve into topics such as coagulation rebalancing, ammonia clearance, neurocritical care monitoring, and intracranial pressure management in children with severe conditions.

• Deep A, Nagakawa S, Tissieres P. Non-transplant options in paediatric acute liver failure-what is new?. Intensive Care Med. 2022;481:114-117.
• Habib M, Roberts LN, Patel RK, Wendon J, Bernal W, Arya R. Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. Liver Int. 2014;345:672-678.
• Slack AJ, Auzinger G, Willars C, et al. Ammonia clearance with haemofiltration in adults with liver disease. Liver Int. 2014;341:42-48.
• Hunt A, Tasker RC, Deep A. Neurocritical care monitoring of encephalopathic children with acute liver failure: A systematic review. Pediatr Transplant. 2019;237:e13556.
• Kochanek PM, Adelson PD, Rosario BL, et al. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022;53:e220891.