New Biology of Breast Cancer and Its Therapeutic Implications

Explore the latest advancements in breast cancer biology and their therapeutic implications in this comprehensive lecture. Delve into the complex nature of breast cancer as a family of diseases, each requiring unique approaches. Learn about various breast cancer subtypes, the role of estrogen, and the development of targeted therapies like Tamoxifen. Understand the mechanisms of cancer cell division and discover new drugs emerging from clinical trials. Examine the impact of Herceptin and other targeted therapies on survival rates. Investigate the importance of DNA repair in cancer treatment, including the role of PARP inhibitors. Gain insights into the potential of immunotherapy in breast cancer treatment, focusing on T cells and checkpoint inhibitors. Analyze key clinical trials and their outcomes, providing a comprehensive overview of current research directions in breast cancer therapy.

Introduction
Family of Diseases
Breast cancer subtypes
Estrogen
Tamoxifen
Cell Division
Cancer Cell Division
New Drugs
Monarch II
Herceptin
ligand
idle curiosity
dimerization
Bonnie and Clyde
chaperone
clinical trials
survival curves
trastuzumab
high nuclear grade
mutations
chemotherapy
PARP
DNA Repair Toolkit
Olympiad Trial
Neighborhood Watch
Immune System
T Cells
Star Trek Fans
The Love
PD1 PDL1
Keynote Study
Breast Cancer Trials