Neuropathology of SARS-CoV-2 as Revealed by Spatial Biology

Explore the neuropathology of SARS-CoV-2 through spatial biology in this 49-minute webinar presented by Dr. Susanne Krasemann. Delve into the neurologic dysfunctions associated with COVID-19, including loss of smell and taste, seizures, and stroke. Learn which cells of the blood-brain barrier are infected by SARS-CoV-2 and understand the significance of interferon-gamma signaling in infected brain capillary endothelial-like cells. Discover how spatial transcriptomics can be applied to study gene expression in FFPE tissue sections. Examine topics such as microglial nodules, lung tissue analysis, brain barrier models, and inflammatory profiles. Gain insights into research methods, including immunofluorescence analysis, electron microscopy, and single-cell analysis. Participate in a live Q&A session addressing questions on protein aggregates, antibodies, and glucose uptake in the blood-brain barrier.

Introduction
What is Covid19
Neuropathology of Covid
Neuropathology of Covid19
microglial nodules
Lung tissue
Brain barrier model
Immunofluorescence analysis
Replication
Electron Microscopy
Fluorescent Dye
Inflammatory Profile
Receptors
Methods
Summary
Thank you
Live QA
Does SARSCoV2 increase protein aggregates
Single cell analysis
Antibodies
Glucose uptake
Glucose uptake in the bloodbrain barrier
Wrapup