Multifactorial Inheritance

Explore the principles of multifactorial inheritance in this 22-minute video lecture by Dr. Bruce Korf for OPENPediatrics. Delve into evidence supporting multifactorial inheritance, models explaining this genetic concept, and the genetics of common disorders. Learn about familial clustering, lambda variables, and how to interpret odds ratios in genome-wide association studies. Examine the paradigm of genetic liability and its interaction with environmental factors in disease development. Gain insights into empirical data used for genetic counseling and understand the concept of missing heritability in complex traits. Enhance your understanding of how genetics integrates into medical practice and its potential impact on disease prevention and treatment.

Introduction
The Paradigm
The Evidence
concordance
measurement of heritability
correlation
model
Linkage disequilibrium
Association studies
Genomewide associations
Odds ratio
Interpreting odds ratios
Missing heritability
What accounts for that
Conclusion