Individual-level Tissue-Specific Imputed Transcriptomes in Drug Target Prioritization and Disease Risk Prediction

Explore a 39-minute lecture from the Medical and Population Genetics Primer series at the Broad Institute, focusing on individual-level tissue-specific imputed transcriptomes in drug target prioritization and disease risk prediction. Delve into complex trait genetics, covering topics such as trait-relevant tissues, transcriptome imputation, druggable gene prioritization, and gene expression-based risk prediction. Learn about the joint analysis of Transcriptome-Wide Association Studies (TWAS) and co-localization, as well as Polygenic Risk Scores and their applications in risk discrimination and group stratification. Gain insights into phenome-wide scans for established drug targets and understand the key takeaways from this comprehensive overview of cutting-edge genetic research techniques.

Intro
Introduction and Background
Trait-relevant tissues and transcriptome imputation
Prioritize druggable genes for phenotypes of interest
Joint analysis of TWAS and co-localization
Gene expression-based risk prediction
Analysis overview
Polygenic Risk Score
Risk discrimination and group stratification
Phenome-wide scans for established drug targets
Take-home message