Modern Radiation Therapy Techniques in the Treatment of Esophageal Cancer - Ann C. Raldow, MD, MPH

Explore modern radiation therapy techniques for treating esophageal cancer in this informative 32-minute video lecture by Dr. Ann C. Raldow, a radiation oncologist from UCLA. Learn about the role of radiation in esophageal cancer treatment, various radiation therapy types, the patient treatment process, and common acute and late side effects. Gain insights into esophageal cancer epidemiology, risk factors, anatomy, clinical presentation, and workup. Understand the treatment paradigm, radiation therapy basics, and the impact of DNA damage on cancer cells. Discover external beam radiation therapy techniques, simulation processes, and dose constraints. Explore key clinical trials and studies, including the CROSS trial, ESOPRESSO study, and ARTDECO study, which have shaped current treatment approaches. Enhance your knowledge of esophageal cancer management and the latest advancements in radiation therapy techniques.

Intro
Disclosures
Esophageal Cancer Outline
Epidemiology
Risk Factors
Anatomy
Clinical Presentation
Workup
Treatment Paradigm
What is Radiation Therapy?
How Does Radiation Kill Cancer Cells?
Impact of DNA Damage
How do the normal cells survive?
Fractionation
External Beam Radiation Therapy
Simulation
Dose Constraints
Esophageal Cancer Timeline
Van Hagen, CROSS
A Randomized Phase III Trial on the Role of Esophagectomy in Complete Responders to Preoperative Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESOPRESSO) (Park, Anticancer Res. 2019)
ESOPRESSO (Park, Anticancer Res. 2019)
Disease-free survival, progression-free survival, time to progression, and overall survival according to treatment arm
A multi-center, randomized, prospective study evaluating the optimal radiation dose of definitive concurrent chemoradiation for inoperable esophageal squamous cell carcinoma (Xu, ASCO 2018)
A randomized controlled phase Ill multicenter study on dose escalation in definitive chemoradiation for patients with locally advanced esophageal cancer: ARTDECO study (Hulshof, GIASCO 2020)
Conclusion