Modelling Immunity to Malaria

Explore the complexities of malaria immunity modeling in this 29-minute lecture from the Workshop on Modelling Immunity. Delve into the burden of malaria, its life cycle, and heterogeneity in prevalence. Examine within-host dynamics, antigenic variation, and the properties of antigenically varying proteins. Learn about modeling human immune responses and within-host dynamics, focusing on the role of immunity and heterogeneities. Investigate human-mosquito transmission models, tracking population immunity, and PDE models with immunity feedback. Discover the dynamics of infectious diseases, malaria parasite diversity, and multi-scale frameworks. Gain insights into parasite population richness and diversity through this comprehensive overview of current research in malaria immunity modeling.

Intro
Outline
Burden of malaria
Malaria life cycle
Heterogeneity in malaria prevalence
Within-host malaria dynamics
Antigenic variation in a single infection
Properties of antigenically varying proteins
Modeling the human immune response
Modeling within-host dynamics
Role of immunity
Heterogeneities in the model
Role of heterogeneities
Drivers of within-host dynamics
Human-mosquito transmission model
Tracking the population immunity
PDE model with immunity feedback
Response of immunity profiles to change
MRC: Dynamics of Infectious Disease
Malaria parasite diversity
Multi-scale framework
Multi-scale model
Parasite population richness
Parasite population diversity
Summary
Acknowledgements
Thank you!