Metabolic Barriers to Tumor Immunity in Pancreatic Cancer

Explore the complex relationship between tumor metabolism and immune function in pancreatic cancer through this 33-minute webinar presented by Dr. Alex Muir, assistant professor at the University of Chicago. Delve into the microenvironment of solid tumors and its impact on immunotherapeutic treatments, focusing on how abnormal nutrient availability affects immune cell function. Learn about interstitial fluid profiling techniques for measuring nutrient stress in pancreatic ductal adenocarcinoma (PDAC) and discover how arginine depletion and phosphoethanolamine levels influence T cell expansion and function. Gain insights into potential strategies for improving adoptive T cell therapy in pancreatic cancer treatment.

Intro
Immunotherapy has become an important clinical tool for a number of malignancies...
Competition of cancer cells and immune cells for nutrients can keep the immune system from killing tumors
Interstitial fluid profiling allows us to measure nutrient stress in the PDAC TME...
and develop model systems to study how nutrient stress impacts PDAC biology
TIFM exposure blocks EXPANSION and FUNCTION
Arginine depletion in TIFM inhibits T cell EXPANSION but not FUNCTION
Reducing tumoral phosphoethanolamine levels improves adoptive T cell therapy