Lessons from the Largest Genome-Wide Association Study of Human Height

Explore the findings from the largest genome-wide association study on human height in this 38-minute conference talk by Loic Yengo at the Computational Genomics Summer Institute (CGSI) 2022. Delve into the study design, key discoveries, and implications of analyzing data from 5.4 million individuals of diverse ancestries. Learn about the variant identified on chromosome 12, potential explanations for its effects, and the enrichment of variance in height-associated genetic variants. Examine the heritability analysis, rare variance analysis, and the concept of saturation in genetic studies. Gain insights into the collaborative efforts behind this groundbreaking research and its significance in understanding the genetic basis of human height.

Introduction
Outline
Why Study Height
What We Knew Before
Collaborators
Study
Study Design
Variant in chromosome 12
Possible explanations
Enrichment of variance
Heritability analysis
Rare variance analysis
Saturation