Linkage Disequilibrium - Introduction to Genomics Theory

Explore the fundamental concept of linkage disequilibrium (LD) in this beginner-friendly genomics lecture. Delve into the importance of LD in revealing population history and selection pressures, as well as its applications in various genomic studies. Learn about LD block structure, its relationship with genetic distance, and metrics used to measure LD, including disequilibrium coefficients (D and D') and correlation (r2). Begin with a recap of previous lectures, compare LD to Mendelian rules, and conclude with a comprehensive summary. This 33-minute video is part of a larger genomics theory series, offering a solid foundation for understanding single nucleotide polymorphism (SNP) data and its significance in genomic research.

- Summary from previous lectures
- General definitions and comparison to Mendelian rules
- LD block structure
- Importance of LD in genomics
- LD and genetic distance
- disequilibrium coefficient D and D' as metric of LD
- Correlation r2 as a metric of LD
- Summary of the lecture