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Columnar Nucleosome Stacking Dictates NCP and Telomeric Chromatin Condensation

Offered By: Erwin Schrödinger International Institute for Mathematics and Physics (ESI) via YouTube

Tags

Telomeres Courses Nucleosomes Courses

Course Description

Overview

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Explore the critical role of nucleosome stacking in chromatin compaction through this 28-minute conference talk from the Workshop on "Chromatin Modeling" at the Erwin Schrödinger International Institute. Delve into the formation of stacked columns by isolated nucleosome core particles (NCPs) in the presence of multivalent cations, and examine how this process can be modeled using multi-scale coarse-grained simulations. Discover recent findings on the columnar structure of telomeric chromatin, revealed through Cryo-EM studies, and learn about the role of TRF2 protein in inducing this architecture. Gain insights into the modeling of ion-mediated phase separation of NCPs and understand the importance of telomere maintenance and interactions with shelterin components in chromatin condensation.

Syllabus

Lars Nordenskiöld - Columnar Nucleosome Stacking Dictates NCP and (Telomeric) Chromatin Condensation


Taught by

Erwin Schrödinger International Institute for Mathematics and Physics (ESI)

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