Pathogenetic Mechanisms of Neurodevelopmental Disorders Caused by Dysfunction of Intracellular Transport

Explore a keynote presentation on the pathogenetic mechanisms of neurodevelopmental disorders caused by dysfunction of intracellular transport. Delve into the role of heterotetrameric adaptor protein (AP) complexes in protein sorting and transport vesicle formation within eukaryotic cells. Focus on the AP-4 complex, its connection to autophagy, central nervous system development, and neurodevelopmental diseases. Learn how to classify AP complexes' mediation of protein sorting, analyze AP-4's role in various biological processes, and understand the journey from basic research to elucidating pathogenetic mechanisms and potential therapies. Presented by Dr. Juan S. Bonifacino, Associate Scientific Director at the National Institutes of Health, this webinar offers valuable insights into cellular biology and its implications for neurodevelopmental disorders. Earn PACE credits by watching the presentation and following the provided instructions.

Introduction
Eukaryotic Cell
Endomembrane System
Adapter Protein Complex
Membrane Bound Complex
Clathrin
AP complexes
Presentation
Conclusion
translational implications