Developing mRNA for Therapy - Katalin Karikó - AAAS Annual Meeting

Explore the groundbreaking work of Katalin Karikó in developing mRNA for therapy in this comprehensive conference talk from the AAAS Annual Meeting. Delve into Karikó's four-decade-long research journey focusing on RNA-mediated mechanisms and her goal of creating in vitro-transcribed mRNA for protein therapy. Learn about her co-discovery of nucleoside modifications suppressing RNA immunogenicity, which expanded mRNA's therapeutic potential. Discover the milestones in mRNA structure, delivery methods, and applications in fields such as cardiology. Gain insights into Karikó's collaboration with Drew Weissman and their pivotal patent on nucleoside-modified uridines in mRNA, which laid the foundation for the development of anti-SARS-CoV-2 mRNA vaccines. Moderated by Seema Kumar, this 76-minute talk offers a deep dive into the revolutionary advancements in mRNA technology and its impact on modern medicine.

Introduction
Welcome
Presentation
Milestones
mRNA Structure
mRNA Delivery
Doublestranded mRNA
Synchronized mRNA
Lipofacting mRNA
mRNA delivery to mammalian cells
cardiology
nitric oxide
met Drew Weissman
mRNA Therapy