Schizoaffective Disorders Precision Medicine - Heterogeneity in Schizophrenia

Explore a comprehensive grand rounds lecture on schizoaffective disorders and precision medicine from Johns Hopkins Psychiatry and Behavioral Sciences. Delve into the challenges of heterogeneity in schizophrenia, examining approaches based on clinical phenotype and treatment response. Learn about the Johns Hopkins Schizoaffective Disorders Precision Medicine Center of Excellence (PMCOE) and its organization, guiding hypotheses, and levels of analysis. Discover the clinical components, assessment protocols, and research questions addressed by the PMCOE. Investigate cutting-edge circuitry projects, including thalamo-cortical connectivity abnormalities detected with 7T MRI and electrophysiological studies. Examine cell pathology research, focusing on protein aggregation and extracellular vesicles as potential pathogenic markers. Gain insights into genetic studies involving CUL1 and ANK3, and their implications for mood disorders and schizophrenia. Presented by Russell Margolis, M.D., this lecture offers a deep dive into the latest advancements in understanding and treating schizoaffective disorders through precision medicine approaches.

Intro
The challenge: Heterogeneity in schizophrenia
Approaches to schizophrenia heterogeneity Heterogeneity based on clinical phenotype
Heterogeneity based on treatment response (Hypothesis developed at Hopkins by Fred Nucifora)
Challenges for TRS and UTRS patients
The Johns Hopkins approach to clinical heterogeneity of various diseases: PMCOEs supported by inHealth
Limitations of Precision Psychiatry
Meaning of "schizoaffective" in our PMCOE
PMCOE Organization
Guiding Hypotheses of the PMCOE
PMCOE Levels of analysis
Clinical Component of PMCOE
Johns Hopkins Schizophrenia Patient Populations
Clinical Assessment Protocol
Clinical Questions to be addressed
Mining the EMR for clinical insight
Circuitry Projects
Thalamo-cortical connectivity abnormalities in scz/scz-aff detected with 7T MRI
Challenges of thalamocortical imaging
Solving the problem of cortical layers
Hua group: vascular imaging
Circuitry as probed electrophysiologically (EEG)
Cell pathology: protein aggregation
Insoluble protein detected in -1/3 of post- mortem scz post-mortem brains
Detecting insoluble protein in cells
Extracellular vesicles (Evs): An alternative approach to exploring pathogenic markers in patient cells
Extracellular vesicles: Detection in blood by Gerber Lab
Approach to CUL1: cell and mouse models
ANK3: a gene linked to mood disorder
Schizoaffective Disorder PMCOE Projects