Leveraging High-throughput Functional Characterization Data to Dissect and Annotate Human Regulatory Regions

Explore high-throughput functional characterization data for dissecting and annotating human regulatory regions in this 33-minute conference talk by Jason Ernst at the Computational Genomics Summer Institute (CGSI) 2023. Delve into genome-scale mapping techniques for identifying activating and repressive nucleotides in regulatory regions, drawing insights from Ernst's 2016 Nature Biotechnology paper. Learn about integrative epigenomic and functional characterization assay-based annotation of regulatory activity across diverse human cell types, referencing Ernst's recent bioRxiv preprint. Gain valuable knowledge on leveraging advanced genomic techniques to unravel the complexities of human gene regulation and enhance our understanding of functional genomics.

Ernst J, Melnikov A, Zhang X, Wang L, Rogov P, Mikkelsen TS, Kellis M. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Nat Biotechnol. 80-1190, 2016.