Introduction to Clinical Pharmacology and Therapeutics - Part 1: Overview of Clinical Pharmacology

Explore the fundamentals of clinical pharmacology in this introductory lecture by Dr. Juan J.L. Lertora, part of the NIH Principles of Clinical Pharmacology Course. Gain insights into clinical pharmacology as a translational scientific discipline focused on rational drug development and therapeutic utilization. Delve into topics such as the principles of clinical pharmacology, founders of American clinical pharmacology, professional goals of clinical pharmacologists, and the impact of genetic polymorphisms on drug exposure. Examine adverse drug reactions, genetics in severe drug toxicity, and the consequences of historical drug crises like thalidomide. Learn about the phases of pre-marketing drug development, drug repurposing, and novel FDA-approved indications for repurposed drugs. This comprehensive overview provides a solid foundation for understanding the critical role of clinical pharmacology in modern medicine and drug development.

Intro
Principles of Clinical Pharmacology
COURSE FOCUS
Translational Sciences
FOUNDERS OF AMERICAN CLINICAL PHARMACOLOGY
Partial List of GOLD and MODELL Accomplishments
PROFESSIONAL GOALS OF CLINICAL PHARMACOLOGISTS
Nortriptyline Drug Exposure Impact of CYP2D6 Polymorphism
Adverse Drug Reactions
Genetics and Severe Drug Toxicity
TERFENADINE METABOLISM
Prenatal Drug Exposure: PHOCOMELIA
CONSEQUENCES OF THALIDOMIDE CRISIS
Development and Evaluation of New Drugs
PHASES OF PRE-MARKETING DRUG DEVELOPMENT
Phases of Drug Development
Drug Repurposing (C. Austin, NCATS)
Novel FDA-Approved Indications for "Repurposed Drugs"