Introduction of Organometallic Chemistry

The basic principles of organometallic chemistry will be discussed in this course. Modern chemistry is merged into one from classical organic chemistry and traditional inorganic chemistry. We will shed light on activation of small molecules by metal-ligand complex. We will discuss the stepwise mechanism of insertion of metal into organic molecules and elimination by different pathway. Only catalytic amount of metal can produce the large number of molecules those include drug, natural products, pharmaceuticals, our daily needs, etc. in gigantic quantity.

INTENDED AUDIENCE: Students, Ph.D. scholars, teachers, industry
PREREQUISITES: Nil
INDUSTRY SUPPORT: All Pharmaceutical Industries

Lecture 1 : Introduction of Organometallic Chemistry.
Lecture 2 : Counting of Electrons.
Lecture 3 : Ligand Substitution Reactions.
Lecture 4 : Oxidative Addition [1.Concerted Mechanism].
Lecture 5 : Oxidative Addition [2.SN2 Mechanism].
Lecture 6 : Oxidative Addition [3. Radical Mechanism].
Lecture 7 : Reductive Elimination.
Lecture 8 : Migratory Insertion & Elimination Reactions.
Lecture 9 : Migration & Insertion Reactions.
Lecture 10 : Alpha-Migratory Insertion & alpha-Elimination Reactions.
Lecture 11 : Beta-Migratory Insertion.
Lecture 12 : Beta-Elimination Reaction.
Lecture 13 : Alpha-Abstraction & beta-Abstraction.
Lecture 14 : 4-Center Reactions; [2+2] Reactions.
Lecture 15 : External Attack by a Ligand & Reductive Coupling.
Lecture 16 : Hydrogenation Reaction.
Lecture 17 : Hydrogenation Reaction [Dihydride Catalyst].
Lecture 18 : Stereoselective Hydrogenation Reaction.
Carbonylation Reaction 1. Monsanto Acetic Acid Process 2. Hydroformylation 3. Hydrocarboxylation.
Carbonylation Reaction [1. Hydroformylation 2. Hydrocarboxylation 3. Hydrocyanation].