Innate Immunity - Complement System - Immunology

Delve into a comprehensive 2-hour and 37-minute lecture on innate immunity and the complement system in immunology. Explore the intricate mechanisms of action, including antigen-antibody reactions, complement protein activation, and the roles of various components like C1, C4, and helper T cells. Examine the formation of complexes such as C4B C2B C3B and the function of C3B convertase. Compare gram-positive and gram-negative bacteria, and understand the actions of macrophages and neutrophils. Learn about opsonization, endotoxins, alternate pathways, and the lectin pathway. Investigate mast cell responses, anaphylatoxins, and B cell activation. Gain a thorough understanding of this crucial part of the immune system, its components, and its role in defending the body against pathogens.

Mechanism of Action
Antigen X Antibody Reaction
Complement Protein-C1 Activation
C1 C4 Helper T cells
C1 C4B C2B
C4B C2B C3B Complex
C3B CONVERTASE
C6 C7 C8 C9
GRAM-POSITIVE VS GRAM-NEGATIVE
MACROPHAGES / NEUTROPHILS Action
Opsonin's C3B IgG
Opsonization Process
Endotoxins’ Action On Protein LPS
Alternate Pathway-Mannan
Lectin Pathway
Mast Cell Response
Anaphylatoxin
B Cell Activation
REVIEW