Improving Outcomes - Lessons Learned from Pediatric Sepsis

Explore a comprehensive lecture on improving outcomes for pediatric sepsis patients, delivered by Dr. Thomas P. Shanley, Chairman of Pediatrics at Lurie Children's Hospital and Chief Research Officer at the Stanley Manne Research Institute. Analyze experiences from treating septic children in the PICU and learn strategies for tackling clinical challenges to enhance patient outcomes. Delve into topics such as the epidemiologic burden of sepsis in children, categorization of shock, physiologic basis for shock, and the role of early fluid resuscitation. Examine case studies, drivers of improvement, and advanced methodologies including whole blood assays, gene expression analysis, and microfluidic chip technology for functional response assessment. Gain insights into hemodynamics of pediatric sepsis, post-translational histone modifications, and localized surface plasmon resonance imaging techniques. This 46-minute video, produced by OPENPediatrics, offers valuable knowledge for healthcare clinicians worldwide caring for critically ill children in various resource settings.

Intro
General Principles
Epidemiologic Burden of Sepsis in Children
Categorization of Shock • Hypovolemic shock
Physiologic Basis for Shock
Role of Early Fluid Resuscitation in Pediatric Septic Shock
The Iterative Cycle of Discovery
Hemodynamics of Pediatric Sepsis
Case Study - After Stabilization
Drivers of improvement
Traditional Methodology - Whole Blood Assay
Attenuated Gene Expression vs. Immune Cell Dysfunction
Mechanisms Affecting Gene Expression
Post-Translational Histone Modifications
Activation of Gene-Off Signature
Integrated Microfluidic Chip for Functional Response
Localized Surface Plasmon Resonance (LSPR) Imaging