Impact of Cell Background on Small Compound Target Deconvolution by CETSA Coupled to Mass Spectrometry

Explore the impact of cell background on small compound target deconvolution through a 43-minute webinar presented by Tomas Friman and Daniel Martinez Molina. Delve into the cellular thermal shift assay (CETSA), a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. Learn how CETSA works by assessing changes in thermal stability of ligated proteins when comparing ligand-treated cells to non-treated cells after heat challenge. Gain insights into the application of CETSA coupled with mass spectrometry for small compound target deconvolution and understand how cell background influences this process.

Impact of Cell Background on Small Compound Target Deconvolution by CETSA Coupled to Mass...