Human Molecular Genetics

This is an introductory course designed primarily for students in the undergraduate or masters programs interested in biomedical research, genetic counseling, medicine, and clinical genetics. This course is expected to introduce rapid advancements in our understanding of the role of human genome in health and disease. We would introduce key concepts of inheritance of human traits, pedigree analysis, and chromosome organization. Molecular biology tools used for understanding the genome, gene structure and gene mutations, gene mapping and gene cloning strategies will also be covered. Objectives and outcome of human genome project and the HapMap project will also be discussed at the end.

Fundamentals of central dogma, Part 1.
Fundamentals of central dogma, Part 2.
Fundamentals of central dogma, Part 3.
Chromosome Structure and Function.
Pedigree Analysis.
Complications in Mendelian Pedigree Patterns.
DNA Cloning and Hybridization Techniques - Part 1.
DNA Cloning and Hybridization Techniques - Part 2.
Practice Session 1: Problems Related to Pedigree Analysis.
Practice Session 2: Restriction Fragment Length Polymorphism and its Applications.
Mutations and instability of human DNA (Part 1).
Mutations and instability of human DNA (Part 2).
Animal Models for Human Diseases.
Positional cloning of genes for monogenic disorders.
Human Genome Project and HapMap project.