Human Leucocyte Antigens and Their Applications - Professor Alejandro Madrigal

Explore the intricacies of human leucocyte antigens (HLA) and their applications in stem cell transplantation and advanced cell therapies in this comprehensive 49-minute lecture by Professor Alejandro Madrigal. Delve into the polymorphism of HLA and its crucial role in improving unrelated donor transplantation outcomes. Gain insights into donor selection issues and the increasing knowledge of modified lymphocytes, such as CAR-T and NK cells, for treating malignant haematological conditions. Learn about the immune system, lymphocytes, HLA molecule structure, and the extensive polymorphism of the HLA system. Discover the evolution of stem cell transplantation, from Shirley Nolan's story to the current availability of donors and new technologies. Examine the importance of matching, cytomegalovirus considerations, and post-transplant mortality. Explore advanced therapies, including viral vectors, CAR therapy, and the Yamanaka cocktail. Understand the revolutionary potential of cell therapies and their wide-ranging applications in modern medicine.

Introduction
The Immune System
Lymphocytes
Structure of hla molecule
The most polymorphic system
The number of antigens
Third generation sequencing
Stem cell transplantation
Story of Shirley Nolan
Number of donors
Type of donors
New technology
Matching
Cytomegalovirus
Posttransplant mortality
Tcells
Advanced therapy
Viral vectors
CAR therapy
CAR expansion
Yamanaka cocktail
The project
The process
Differentiation
Revolution in cell therapy
Potential applications