Graft-Versus-Host Disease

Learn about Graft-Versus-Host Disease (GVHD) in this comprehensive 43-minute lecture by Christine Duncan for OPENPediatrics. Explore the intricacies of hematopoietic stem cell transplantation, including stem cell sources and the pathophysiology of acute and chronic GVHD. Discover risk factors, HLA matching, and the National Institute of Health GVHD criteria. Examine the diagnostic features and manifestations of chronic GVHD in various organs, including skin, mouth, lungs, hair, eyes, genitourinary system, and liver. Understand acute GVHD grading and staging for cutaneous, gastrointestinal, and hepatic involvement. Delve into GVHD prevention, treatment options such as steroids and monoclonal antibodies, and secondary therapies. Gain insights into infectious prophylaxis and prognosis for both acute and chronic GVHD. This lecture provides essential knowledge for healthcare professionals caring for critically ill children undergoing stem cell transplantation.

Intro
Hematopoietic Stem Cell Transplant
Sources of Stem Cells
Graft-Versus-Host Disease (GVHD)
Pathophysiology of Acute GVHD
Pathophysiology of Chronic GVHD
Risk Factors for GVHD
HLA Region of Chromosome 6
HLA Matching and GVHD Risk
Risk Factors: Stem Cell Source
Acute vs. Chronic GVHD
National Institute of Health GVHD Criteria
Features of Acute & Chronic GVHD
Chronic GVHD Diagnostic Features: Skin Lichen Planus
Chronic GVHD Diagnostic Features: Mouth
Chronic GVHD Diagnostic Features: Lungs
Chronic GVHD: Hair Manifestations
Chronic GVHD: Oral Manifestations
Ocular GVHD
GVHD: Genitourinary Manifestations
Chronic GVHD: Pulmonary Manifestations
Chronic GVHD: Hepatic Manifestations
Acute GVHD Grading
Acute GVHD: Cutaneous Staging
Acute GVHD: Gastrointestinal Staging
Acute GVHD: Hepatic Staging
Infectious Prophylaxis in GVHD
GVHD Prevention
GVHD Treatment: Steroids
Treatment of Steroid Refractory GVHD
Monoclonal Antibodies
SECONDARY THERAPIES
Acute GVHD Prognosis
Chronic GVHD Prognosis